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Dlaczego publikujemy badania naszego suplementu?

2022-09-160
Transparentność ale co to tak naprawdę znaczy?

Producenci suplementów dla psów w swojej większości unikają odpowiedzi na pytania czy stosują wypełniacze, sztuczne konserwanty, barwniki, dokładną gramaturę składników. Jeżeli jest się czym chwalić to dlaczego tego nie robić? Otóż prawo niestety nie zmusza do informowania nas wszystkich konsumentów, o tych kluczowych dla skuteczności oraz jakości informacji. Jesteśmy pozbawieni realnej oceny tego czy dany produkt to nie w rzeczywistości 100 gram substancji czynnych, czy 70 gram bezwartościowych wypełniaczy.

 

Transparentność to podstawowa cecha Dianamed

Dlatego my jako miłośnicy psów chcąc dostarczać jak najlepszy produkt nie mamy czego się wstydzić, wręcz przeciwnie. Poniżej chwalimy się badaniami oraz informacjami na temat naukowych podstaw naszego składu oraz pełnej zawartości produktu.

Badanie membrany jaja kurzego

 

Publikacje:

1. Comblain F, Barthélémy N, Lefèbvre M, Schwartz C, Lesponne I, Serisier S, Feugier A, Balligand M, Henrotin Y. A randomized, double-blind, prospective, placebo-controlled study of the efficacy of a diet supplemented with curcuminoids extract, hydrolyzed collagen and green tea extract in owner’s dogs with osteoarthritis. BMC Vet Res. 2017 Dec 20;13(1):395. doi: 10.1186/s12917-017-1317-8. PMID: 29262825; PMCID: PMC5738810.

 

2. Kunsuwannachai, Susolos, i Kumpanart Soontornvipart. „Chondroprotective Efficacy of Undenatured Collagen Type II on Canine Osteoarthritis Secondary to Medial Patellar Luxation”. Thai J Vet Med., b.d., 7.

 

3. Ruff, Kevin, Kenneth Kopp, Pamela Von Behrens, Mark Lux, Matthew Mahn, i Matthew Back. „Effectiveness of NEM® Brand Eggshell Membrane in the Treatment of Suboptimal Joint Function in Dogs: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Study”. Veterinary Medicine: Research and Reports Volume 7 (sierpień 2016): 113–21.

 

4. Deparle, L. A., R. C. Gupta, T. D. Canerdy, J. T. Goad, M. D’altilio, M. Bagchi, i D. Bagchi. „Efficacy and Safety of Glycosylated Undenatured Type-II Collagen (UC-II) in Therapy of Arthritic Dogs§”. Journal of Veterinary Pharmacology and Therapeutics 28, nr 4 (2005): 385–90.

 

5. Martello, Elisa, Mauro Bigliati, Raffaella Adami, Elena Biasibetti, Donal Bisanzio, Giorgia Meineri, i Natascia Bruni. „Efficacy of a Dietary Supplement in Dogs with Osteoarthritis: A Randomized Placebo-Controlled, Double-Blind Clinical Trial”. PLOS ONE 17, nr 2 (16 luty 2022): e0263971.

 

6. „Evaluation of The Efficacy of a Dietary Supplement in Alleviating Symptoms in Dogs with Osteoarthritis”. Jfn, 2 grudzień 2019.

 

7. Comblain, F., S. Serisier, N. Barthelemy, M. Balligand, i Y. Henrotin. „Review of Dietary Supplements for the Management of Osteoarthritis in Dogs in Studies from 2004 to 2014”. Journal of Veterinary Pharmacology and Therapeutics 39, nr 1 (luty 2016): 1–15.

 

8. Vilar, José M., Mónica Rubio, Giuseppe Spinella, Belén Cuervo, Joaquín Sopena, Ramón Cugat, Montserrat Garcia-Balletbó, i in. „Serum Collagen Type II Cleavag Epitope and Serum Hyaluronic Acid as Biomarkers for Treatment Monitoring of Dogs with Hip Osteoarthritis”. PLOS ONE 11, nr 2 (17 luty 2016): e0149472.

 

9. Schunck, Michael, Helen Louton, i Steffen Oesser. „The Effectiveness of Specific Collagen Peptides on Osteoarthritis in Dogs-Impact on Metabolic Processes in Canine Chondrocytes”. Open Journal of Animal Sciences 7, nr 3 (5 lipiec 2017): 254–66.

 

10. Barnett M.L., Kremer J.M., St Clair E.W., Clegg D.O., Furst D., Weisman M., Fletcher M.J., Chasan-Taber S., Finger E., Morales A., Le C.H., Trentham D.E. “Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial”. Arthritis and Rheumatism 1998;41(2):290-7.

 

11. Gencoglu, Hasan, Cemal Orhan, Emre Sahin, i Kazim Sahin. „Undenatured Type II Collagen (UC-II) in Joint Health and Disease: A Review on the Current Knowledge of Companion Animals”. Animals 10, nr 4 (kwiecień 2020): 697.

 

12. Turna, Ozge, Aslihan Baykal, Elif Sozen Kucukkara, Asuman Deveci Ozkan, Gamze Guney Eskiler, i Funda Yıldırım. „Evaluation of Curcumin Therapeutic Effects on Histological Subtypes of Canine Mammary Gland Tumours”. Nutrition and Cancer 0, nr 0 (28 styczeń 2022): 1–11.

 

13. Weide, Nina. „Der Einsatz von Gelatinehydrolysat Bei Klinisch-Orthopädisch Gesunden Hunden Und Hunden Mit Chronischen Erkrankungen Des Bewegungsapparates”, 2004.

 

14. Levine, Corri B., Julie Bayle, Vincent Biourge, i Joseph J. Wakshlag. „Effects and Synergy of Feed Ingredients on Canine Neoplastic Cell Proliferation”. BMC Veterinary Research 12 (2016).

 

15. Yurdakok-Dikmen, Begum, Yagmur Turgut, i Ayhan Filazi. „Herbal Bioenhancers in Veterinary Phytomedicine”. Frontiers in Veterinary Science 5 (2018).

 

16. Bhathal, Angel, Meredith Spryszak, Christopher Louizos, i Grace Frankel. „Glucosamine and chondroitin use in canines for osteoarthritis: A review”. Open Veterinary Journal 7, nr 1 (2017): 36–49.

 

17. Wu, Jian, Maiko Fujioka, Kiho Sugimoto, Gang Mu, i Yoshiko Ishimi. „Assessment of Effectiveness of Oral Administration of Collagen Peptide on Bone Metabolism in Growing and Mature Rats”. Journal of Bone and Mineral Metabolism 22, nr 6 (1 listopad 2004): 547–53. https://doi.org/10.1007/s00774-004-0522-2.

 

18. Martello, Elisa, Mauro Bigliati, Donal Bisanzio, Elena Biasibetti, Franco Dosio, Daniela Pastorino, Massimo De-Nardi, i Natascia Bruni. „Effects on Pain and Mobility of a New Diet Supplement in Dogs with Osteoarthritis: A Pilot Study”. Annals of Clinical and Laboratory Research 7, nr 3 (30 kwiecień 2019).

 

19. I mhoff, Darren J., Wanda J. Gordon-Evans, Richard B. Evans, Ann L. Johnson, Dominique J. Griffon, i Kelly S. Swanson. „Evaluation of S-Adenosyl l-Methionine in a Double-Blinded, Randomized, Placebo-Controlled, Clinical Trial for Treatment of Presumptive Osteoarthritis in the Dog”. Veterinary Surgery 40, nr 2 (2011): 228–32.

 

20. Najm WI, Reinsch S, Hoehler F, Tobis JS, Harvey PW. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. [ISRCTN36233495]. BMC Musculoskelet Disord. 2004 Feb 26;5:6. doi: 10.1186/1471-2474-5-6. PMID: 15102339; PMCID: PMC387830.

 

21. Damjanov et al. (2019) NEM® Brand Eggshell Membrane in the Treatment of Pain and Stiffness Associated with Knee Osteoarthritis: An Open Label Clinical Study. Journal of Arthritis, 8(5):1000287.

 

22. Eskiyurt et al. (2019) Efficacy and Safety of Natural Eggshell Membrane (NEM®) in Patients with Grade 2/3 Knee Osteoarthritis: A Multi-Center, Randomized, Double-blind, Placebo-Controlled, Single-crossover Clinical Study. Journal of Arthritis, 8(4):1000285.

 

23. Ruff KJ, Back M, Morrison D, Duncan SA. (2019) Development of a Novel Clinical Trial Design to Evaluate the Effects of Joint Therapeutics on Cartilage Turnover in Healthy Subjects. Journal of Novel Physiotherapies, 9(3):1000415.

 

24. Ruff KJ, Theodosakis J, Morrison D, Duncan SA, Back M, and Aydogan C. (2018) Eggshell Membrane: Beneficial effects of natural eggshell membrane versus placebo in exercise-induced joint pain, stiffness, and cartilage turnover in healthy, postmenopausal women. Clinical Interventions in Aging, 13:285-295.

 

25. Wedekind KJ, Ruff KJ, Atwell CA, Evans JL and Bendele AM. (2016) Beneficial Effects of Natural Eggshell Membrane (NEM) on Multiple Indices of Arthritis in Collagen-Induced Arthritic Rats. Modern Rheumatology, 27(5):838-848.

 

26. Brunello E and Masini A. (2016) NEM® Brand Eggshell Membrane Effective in the Treatment of Pain and Stiffness Asso- ciated with Osteoarthritis of the Knee in an Italian Study Population. International Journal of Clinical Medicine, 7:169-175.

 

27. Sim BY, Bak JW, Lee HJ, Jun JA, Choi HJ, Kwon CJ, Kim HY, Ruff KJ, Brandt K and Kim DH. (2015) Effects of nat- ural eggshell membrane (NEM) on monosodium iodoacetate-induced arthritis in rats. Journal of Nutrition and Health, 48(4):310-318.

 

28. Ruff KJ, Durham PL, O’Reilly A and Long FD. (2015) Eggshell membrane hydrolyzates activate NF-κB in vitro: possible implications for in vivo efficacy. Journal of Inflammation Research, 8:49-57.

 

29. Danesch U, Seybold M, Rittinghausen R, Treibel W and Bitterlich N. (2014) NEM Brand Eggshell Membrane Effective in the Treatment of Pain Associated with Knee and Hip Osteoarthritis: Results from a Six Center, Open Label German Clinical Study. Journal of Arthritis, 3(3):136.

 

30. Ruff KJ and DeVore DP. (2014) Reduction of pro-inflammatory cytokines in rats following 7-day oral supplementation with a proprietary eggshell membrane-derived product. Modern Research in Inflammation 3(1):19-25.

 

31. Benson KF, Ruff KJ and Jensen GS. (2012) Effects of Natural Eggshell Membrane (NEM) on Cytokine Production in Cultures of Peripheral Blood Mononuclear Cells: Increased Suppression of Tumor Necrosis Factor-a Levels After In Vitro Digestion. Journal of Medicinal Food, 15(4):360-368.

 

32. Ruff KJ, Endres JR, Clewell AE, Szabo JR and Schauss AG. (2012) Safety evaluation of a natural eggshell mem- brane-derived product. Food and Chemical Toxicology, 50:604-611.

 

33. Ruff KJ, Winkler A, Jackson RW, DeVore DP and Ritz BW. (2009) Eggshell Membrane in the Treatment of Pain and Stiffness from Osteoarthritis of the Knee: A Randomized, Multicenter, Double Blind, Placebo Controlled Clinical Study. Clinical Rheumatology, 28:907-914.

 

34. Ruff KJ, DeVore DP, Leu MD and Robinson MA. (2009) Eggshell Membrane: A Possible New Natural Therapeutic For Joint & Connective Tissue Disorders. Results From Two Open-label Human Clinical Studies. Clinical Interventions in Aging, 4:235-240.

 

35. Satyaraj, Ebenezer, Arleigh Reynolds, Robyn Engler, Jeff Labuda, i Peichuan Sun. „Supplementation of Diets With Spirulina Influences Immune and Gut Function in Dogs”. Frontiers in Nutrition 8 (2021).

 

36. Campigotto, Gabriela, Davi F. Alba, Maiara M. Sulzbach, Daiane S. Dos Santos, Carine F. Souza, Matheus D. Baldissera, Samanta Gundel, i in. „Dog food production using curcumin as antioxidant: effects of intake on animal growth, health and feed conservation”. Archives of Animal Nutrition 74, nr 5 (2 wrzesień 2020): 397–413.

 

37. Jewell, D. E., P. W. Toll, K. J. Wedekind, i S. C. Zicker. „Effect of Increasing Dietary Antioxidants on Concentrations of Vitamin E and Total Alkenals in Serum of Dogs and Cats”. Veterinary Therapeutics: Research in Applied Veterinary Medicine 1, nr 4 (2000): 264–72.

 

38.Hosea Blewett, Heather Joy. „Exploring the Mechanisms behind S- Adenosylmethionine (SAMe) in the Treatment of Osteoarthritis”. Critical Reviews in Food Science and Nutrition 48, nr 5 (8 maj 2008): 458–63.

 

39. Reichling, J., H. Schmökel, J. Fitzi, S. Bucher, i R. Saller. „Dietary Support with Boswellia Resin in Canine Inflammatory Joint and Spinal Disease”. Schweizer Archiv Fur Tierheilkunde 146, nr 2 (luty 2004): 71–79.

 

40. Musco, Nadia, Giuseppe Vassalotti, Vincenzo Mastellone, Laura Cortese, Giorgia della Rocca, Maria Luce Molinari, Serena Calabrò, Raffaella Tudisco, Monica Isabella Cutrignelli, i Pietro Lombardi. „Effects of a nutritional supplement in dogs affected by osteoarthritis”. Veterinary Medicine and Science 5, nr 3 (17 lipiec 2019): 325–35.

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